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Product Name |
ThankGod Relief Capsules™ |
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Composition |
Each hard gelatin capsule
contains Euphorbia prostrata Extract 100 mg. |
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Introduction |
Euphorbia prostrata is a
common herb found all over India especially in foot
hills of Himalayas. The extract of Euphorbia prostrata
has been found to have significant anti-inflammatory,
analgesic, haemostatic and wound healing properties.
Preclinical and clinical trials have demonstrated its
efficacy as an anti-hemorrhoid agent.
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Pharmacology |
The major flavonoid
components of Euphorbia prostrata Extract are Apigenin,
Luteolin, Apigenin-7-glucoside and Luteolin-7-glucoside.
The major phenolic compounds present are Gallic acid,
Ellagic acid and Tannins.
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Actions and effects |
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- Anti-oxidant
activity :Flavonoids
and phenolic compounds of the extract have
anti-oxidant property which also contributes in
healing of inflammatory tissue damage in hemorrhoidal
conditions.
- Anti-hemorrhoidal
activity: Euphorbia prostrata Extract has been
shown to have significant anti-hemorrhoidal activity
as demonstrated by ano-rectal weight: body weight
ratio model in rats.
- Anti-inflammatory
activity: Various components of Euphorbia prostrata Extract are known to affect inflammatory
response to antigens. Apigenin-7-glucoside inhibits
release of histamine, generation of hydrogen peroxide
and leucocyte infiltration at inflammatory site.
Luteolin-7-glucoside decreases leucocyte infiltration.
- Analgesic activity:
Analgesic activity of Euphorbia prostrata Extract
may be ascribed to inhibition of exudates formation
and migration of neutrophils and monocytes.
- Haemostatic
activity: Flavonoids have a significant effect on
in terms of rapid cessation of bleeding and reduced
risk of relapse in Piles (hemorrhoids).
- Vasoprotective
activity: Flavonoids tend to decrease capillary
permeability and increase capillary resistance.
Several mechanisms have been proposed such as
inhibition of ascorbic acid oxidation, blood cell
aggregation and stimulation of pituitary-adrenal axis.
- Anti-allergic
activity: Apigenin and Luteolin inhibit basophil
histamine release and neutrophil beta glucoronidase
release, thus exerting anti-allergic effects.
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Indications |
ThankGod Relief Capsules™
are intended for long term relief from bleeding, pain,
anal discomfort and inflammation in hemorrhoids
(especially first and second degree hemorrhoids).
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Dosage |
One capsule daily in the
morning on empty stomach. Do not exceed the recommended
doses. Keep out of reach of children.
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Precautions |
Stop use and consult your
physician if bleeding is excessive/ if the bleeding
persists/ if there is passage of black tarry stools/ if
there is seepage or protrusion in the anal area.
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Caution |
The safety of ThankGod
Relief Capsules™ has not been established in pregnant, lactating
mothers, in children and in patients on anticoagulant
therapy.
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Adverse effects |
The drug is usually well
tolerated. However, nausea, dyspepsia, abdominal pain,
diarrhea, headache and dry mouth have been reported in
some cases.
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Drug interactions |
Not known |
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Overdosage |
Consult the Physician
immediately |
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Storage |
Store in a cool and dry
place away from direct sunlight and moisture
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Supply |
ThankGod Relief Capsules™
are supplied in a “mooda” shaped plastic bottle
containing 14 capsules and in a blister pack of 7
capsules |
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Proprietary Ayurvedic
Medicine * based
upon the stability data of ThankGodTM
Capsules & Tablets it was observed that the stability
profile of the tablets was found to be better than
capsules, hence finished dosage form has now been
changed to tablets |
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